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Department of Pharmaceutical Chemistry

Course Title: Medicinal and Pharmaceutical Chemistry 2

Code: 802

A- Basic Information

Programme(s) on which the course is given: Bachelor of Pharmaceutical Sciences
Department of responsible for offering the course: Department of Pharmaceutical Chemistry
Department of responsible for teaching the course: Department of Pharmaceutical Chemistry
Academic year Fourth year – Second semester
Course title and code Pharmaceutical Chemistry 2, 802
Contact hours (credit hours): Lecture: 3 (3), Practical: 3 (1), Total: 6 (3+1)
Course Coordinator Prof. Dr. Samir El Moghazy.

B- Professional Information

The course aim and intended learning outcomes are based on that mentioned in the programme specifications, with more course-related specific details.

  1. Overall aims of course:
    After completing this course, the student should gain the following competencies:
    1. Able to predict the biological response from a chemical structure of compounds affecting various receptors or systems.
    2. Able to predict the biochemical mechanism of action of a biologically active compound from its chemical structure.
    3. Able to suggest suitable synthetic and analytical methods for drugs.
    4. Gain the skills and attitude required for the responsible practice of pharmacy.
    5. Studying some drug classes such as: antibiotics, anticancer, antiseptic, disinfectant, antiprotozoal, antifungal, antimalarial and anti-inflammatory agents.
  2. Intended Learning Outcomes of Course (ILOs)
    a-Knowledge and Understanding:
    By the end of this course, the student should be able to demonstrate knowledge and understanding of:
    1. Chemistry of different groups of chemotherapeutic agents.
    2. Methods of synthesis and analysis of the studied drugs.
    3. Mechanisms of action of the studied drugs.
    4. Pharmacological and regulatory requirements.
    5. Tests for identification of some drugs.
    6. Pharmacological properties of drugs including mechanisms of action, therapeutic uses of some drugs, in addition to their adverse reactions, interactions with other medicine and their significance in treatment, dosage and contra-indications.
    7. The relationship between the chemical structure and the activity of various drugs and how to optimize the activity of a given drug
    8. Offering the knowledge's about the new strategies in the synthesis of pharmaceutical compounds.
    9. Mode of action of studied classes of therapeutic drugs.
    10. Methods of biostatistical analysis and pharmaceutical calculations.
    11. Principles of different analytical techniques using GLP guidelines and validation procedures.
    12. Principles of isolation, synthesis, purification and standardization methods of pharmaceutical compounds.
    b- Intellectual Skills:
    By the end of this course, the student should be able to:
    1. Predict the appropriate methods of isolation, synthesis, purification, identification and analysis of the studied drugs.
    2. Demonstrate how to avoid undesirable side effects of the studied drugs.
    3. Demonstrate knowledge and critical understanding of essential facts, concepts, principles and theories related to the subject areas identified under knowledge and understanding.
    4. Apply in practice settings the knowledge and understanding are required to meet the needs of patients and other health care professionals.
    5. Predict problems related to qualitative and quantitative information's extending to situations where evaluations have to be made on the basis of limited information.
    6. Recognize pharmaceutical science materials and arguments clearly and correctly in writing and orally to both specialist and lay audience.
    7. Predict structure activity relationship.
    8. Apply qualitative and quantitative analytical and biological methods for QC and assay of raw materials as well as pharmaceutical preparations.
    9. Utilize the pharmacological basis of therapeutics in the proper selection and use of drugs in various disease conditions.
    10. Interpret experimental results as well as published literature.
    c- Professional and Practical Skills:
    By the end of this course, the student should be able to:
    1. Identification of some drugs (by chemical tests) in various pharmaceutical preparations.
    2. Use effectively some skills in the synthesis and the quantitative estimation of some drugs.
    3. Extract, isolate, synthesize, purify, identify, and/ or standardize active substances from different origins.
    4. Evaluate critically and interpret data derived from laboratory observations and measurements.
    5. Analyze some pharmaceutical compounds and some drugs using infra-red spectroscopy.
    6. Use effectively HPLC method for the estimation of some pharmaceutical compounds and some drugs.
    7. Solve some problems in HPLC.
    8. Use different in operating different pharmaceutical equipments and instruments and use emerging technologies.
    9. Select medicines based on understanding of etiology and pathophysiology of diseases.
    10. Use the proper pharmaceutical and medical terms, abbreviations and symbols in pharmacy practice.
    d- General and Transferable Skills:
    1 - ............................................
  3. Course Contents
    Topics No. of hours Tutorial / Practical Lecture
    β-Lactam antibiotics. 6 - 6
    Non β-Lactam antibiotics. 6 - 6
    Antiseptic and disinfectant agents. 4 - 4
    Sulphonamides. 2 - 2
    Antimalarial agents. 2 - 2
    Antiprotozoal agents. 2 - 2
    Anthelmintic and antibilharzial agents. 3 - 3
    Antifungal agents. 2 - 2
    Anti T.B and antileprotic agents. 3 - 3
    Antiviral agents. 2 - 2
    Antineoplastic drugs. 2 - 2
    Analgesics, non steroidal anti-inflammatory drugs, Opioids analgesics. 8 - 8
    Pharmaceutical analysis of some of the studied drugs. (Titrimetric, spectrophotometric, IR spectroscopic application for some of the selected drugs, in addition to drug identity). 30 30 -
    Practical assessment of the above topics, tutorials. 6 6 -
    Total 78 36 42
  4. Teaching and Learning Methods
    4.1………Lectures.
    4.2……….Information collection from different sources.
    4.3……….Practical sessions.
  5. 5 - Student Assessment Methods
    5.1……Written exam to assess knowledge and understanding of theoretical information as well as higher intellectual skills.
    5.2……Practical exam to assess practical skills acquired.
    5.2……Practical exam to assess practical skills acquired.
    5.4……Lab work to assess practical skills

    Assessment Schedule
    Assessment 1 … Written………………… Week (15 – 18)
    Assessment 2 … Practical……………….. Week (12)
    Assessment 3 … Oral……………………. Week (15 – 18)
    Assessment 4 … Lab work………………. Every week
    Weighting of Assessments
    Mid-Term Examination   0 %
    Final-term Examination 50 % 100 Marks
    Oral Examination             15 % 30 Marks
    Practical Examination    30 % 60 Marks
    Lab work                             2.5 % 5 Marks
    Tutorials                             2.5 % 5 Marks
    Total                                    100% (200 Marks)
  6. List of References
    • Course Notes
      - Supplied by the department.
    • Essential Books (Text Books)
      - Block, J. H. and Beale, J. M.; "Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry", 11 th Ed., Lippincott Williams & Wilkins, A Wolters Kluwer Company, Philadelphia, (2004).
      - Williams, D. A. and Lemke, T. L.; "Foye's Principles of Medicinal Chemistry", 5 th Ed., Lippincott Williams & Wilkins, A Wolters Kluwer Company, Philadelphia, (2002).
      - Abraham, D. J.; "Burger's Medicinal Chemistry and Drug Discovery volume 3: Cardiovascular Agents and Endocrines", 6 th Ed., A John Wiley & Sons, Inc., Publication, New Jersey, (2003).
      - Gerbino, P. P.; " Remington The Science and Practice of Pharmacy", 21 st Ed., Lippincott Williams & Wilkins, by the University of the Sciences in Philadelphia, (2006).
      - Sweetman, S. C., "Martindale, The Complete Drug Reference", 34 th Ed., The Pharmaceutical Press, London, Chicago, (2005).
      - Howland, R. D., Mycek, M. J., Harvey, R. A. and Champe, P. C.; "Lippincott’s Illustrated Reviews : Pharmacology”, 3 rd Ed., Lippincott Williams & Wilkins, Philadelphia, (2006).
      - Different Pharmacopoeias (The United States Pharmacopeia (USP 30), The National Formulary (NF 25), Asian Ed., (2007).
      The British Pharmacopoeia, Her Majesty's Stationary Office, London, UK, (2007).
      The European Pharmacopoeia, 5 th Ed., Council of Europe, Strasbourg, (2005).
      The Egyptian Pharmacopoeia,(1986).
      - O’Neil, M. J., Heckelman, P. E., Koch, C. B., Roman, K. J., Kenny, C. M. and D'Arecca, M. R.; “The Merck Index, An Encyclopedia of Chemicals, Drugs and Biologicals”, 14 th Ed., Merck Research laboratories Division of Merck & Co., Inc. Whitehouse Station, NJ, USA, (2006).
      - Other available medicinal chemistry books.
    • Recommended Books
      - Kumar, P. and Clark, M.; "Clinical Medicine", 6 th Ed., Elsevier Limited, (2005).
      - Nissen, D.; "2004 Mosby's Drug Consult", Mosby, Elsevier, (2004).
    • Periodicals, Web Sites, … etc
      - www.sciencedirect.com
      - www.pubmed.com.
      - www.drugs.com
  7. Facilities Required for Teaching and Learning
    - Highly equipped laboratories, computers, transparencies, overhead projectors, data show, white board and different glass wares.

Course coordinator:
Name: Prof. Dr.Samir El Moghazy

Head of Department : Prof. Dr. Nehad El-Sayed Abou-ElMagd
Date: 4 /2010

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